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关键词：
Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models
书目信息
ISBN：
9781000430738
本馆索书号：
中图分类号：
Q25
中文译名：
细胞信号转导系统生物学：重复主题和定量模型
作者：
James E. Ferrell
编者：
语种：
英语
出版信息
出版社：
CRC Press
出版地：
出版年：
2021
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原版
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内容简介：
How can we understand the complexity of genes, rnas, and proteins and the associated regulatory networks??one approach is to look for recurring types of dynamical behavior.?mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models.?clever, careful experiments test these models and their basis in specific theories.?this textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing upon modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and non-linear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations.
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