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关键词:
Human Biological Aging: From Macromolecules to Organ Systems
书目信息
ISBN:
9781118967027
本馆索书号:
中图分类号:
Q95
中文译名:
作者:
Glenda Bilder
编者:
语种:
英语
出版信息
出版社:
Wiley
出版地:
出版年:
2016
版本:
版本类型:
原版
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卷期:
文献信息
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前言:
摘要:
Human Biological Aging will introduce the student tohuman aging from the level of macromolecules to organ systems. Agechanges in proteins, DNA, polysaccharides and lipids are discussedrelative to known age-related alterations in structure and functionproduced by free radicals and oxidants. At the cellularlevel, age-dependent mechanisms that diminish organelle functionare described. Cellular phenomena of replicative senescenceapoptosis, autophagy and neuroplasticity are detailed as to theircontribution to compromised cellular functions. The uniqueage changes of each organ-system are presented. Someimportant changes include photo-aging in the integument, increasedairway resistance, decreased thoracic chest compliance andreduction of active lung tissue in the pulmonary system,endothelial dysfunction in the cardiovascular system, cognitivechanges influenced by negative and positive neuroplasticity in thecentral nervous system, the impact of presbyopia, presbycusis andsensory fiber loss on sensory perception, sarcopenia and dynapeniain the skeletal muscle system, the effects of menopause, alteredstress response and loss of growth hormone in thehypothalamic pituitary system, age changes in bone remodeling andmodeling in the skeletal system and prostatic hypertrophy andurinary incontinence in the excretory system.The selection of book material is based on Dr.Bilder's lectures developed over the years as the teacher fora Biology of Aging course at Gwynedd MercyUniversity. Her lectures covered biological aging fromthe bottom upmacromolecules to organ-systems. Additionally the student is introduced to methods and measurementsin aging and the tools to critique future findings, the effects ofclassic caloric restriction studies and newer gene manipulationsand the evolutionary theory of aging that accepted biological agingas truly biological. Major age-related diseases are absentfrom this textbook as biogerontologists consider disease distinctfrom aging. Instead this textbook includes many agechanges that highlight how aging is a risk factor for disease.To fully understand biological aging, it is necessary to includeprimary biological content and then to develop aginginsights. For example, to understand the role of agingin the development of sarcopenia and dynapenia, anappreciation of skeletal muscle structure and function isimportant, after which age changes of sarcopenia and dynapenia andthe influence of exercise and protein consumption becomesmeaningful. Similarly comprehension of the theories of agingrequire rudimentary knowledge of oxidation/reduction reactions,protein function, cell organelles, mitosis, acquired immunity, andevolution, to name a few basic biological concepts. Withoutsome biological fundamentals, the student of biological agingstruggles to learn the essentials of biological aging and toappreciate the research advances on aging. With regards to format, basic knowledge is given first. Biological terms are defined; key questions to aid with studyare given with each chapter. Specifically the reader willlearn the current theories of aging, their origins and their valuein the scientific literature. The reader will learn whyaging is not a disease but a risk for disease. The readerwill understand how age changes are measured and appreciate thedifficulties of obtaining accurate observations on aging. Thus, in forthcoming findings, the student will be equipped todiscriminate between hype and worthwhile advances. This textbookwill provide the reader with an overview of the major animal modelsof aging so that the relevance of this data on conserved mechanismsis evident. Finally, this textbook will give to the reader aframework to incorporate new information. The reader willrealize the significance of the health span and gain competency toselect lifestyle choices that prolong it.
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全文链接:
http://www.itextbook.cn/f/book/bookDetail?bookId=cf149a79e8024a78a27fde8c3d0aca21
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